Alluzience: is this the best botox till this date?
Introduction
Alluzience® botulinum toxin (a.k.a. Botox) is a revolutionary new take on the traditional botulinum toxin treatment. To read more about botulinum toxin and the differences, read here. If you want to know more about the treatment, read here. This brand is the newest botulinum toxin brand on the market. Unlike other botulinum toxin brands, Alluzience® is the first botulinum toxin that is 100% vegan and ready to use. It employs natural ingredients to create a very precise, safe and highly effective formula!
Alluzience® is Quick…
What sets Alluzience® apart is its ability to quickly work into facial muscle tissue beneath the skin to dramatically reduce the appearance of wrinkles. By targeting specific neuromuscular compounds, this powerful formula relaxes muscles and smooths out your skin.
8 years younger…
By providing your face with Alluzience®, it can help you look up to eight years younger. So if you’re looking for an easy way to reduce wrinkles and feel more confident in your own skin, Alluzience® Botox could be the answer for you!
How does it work?
In medical terms
Alluzience® botulinum toxin is a type A botulinum toxin. This newest brand of botulinum toxin is fermented from the bacteria clostridium botulinum like other brands do. Furthermore, Alluzience® consists of heavy chain (100 kDa) and light chain (50 kDa) proteins, which are connected with sulfur bridges. When injected in the target area, it prevents the release of acetylcholine from synapses. It does so by binding receptors from the presynaptic membrane. Thus, exocytosis from acetylcholine is being inhibited. By this process movement of the muscles are cancelled and the wrinkles are smooth out.
Normal language
Alluzience vs Some other brands
Compared to Dysport®:
Like Dysport®, Alluzience® starts quickly working. Even after 24 hours you can start seeing the difference! On average it takes like 2-3 days like Dysport®. But, one of the additional benefits of Alluzience® is that the results extend to 6 months instead of 3-4 or maybe 5 months with Dysport®. Both of these brands have the same dosage units (sU or Speywood Units) and are made of exactly the same type of botulinum toxin type A, Abobotulinum toxin. Another benefit of Alluzience® is, that it is already prepared beforehand and that it does not require any calculation by your doctor. This way Alluzience® gives more exact dosage and thus more safety in application.
Compared to Bocouture®/Xeomin®:
Bocouture® is being calculated in units while Alluzience® is being calculated in sU units. 1 unit of bocouture® corresponds to 2.5 sU units of Alluziance® in matter of botulinum toxin strenght. Further, bocouture doesn’t contain complexing proteins, which can trigger your auto-immune system. Your auto-immune system recognizes the complexing proteins and therefore the botulinum toxin may not work well overtime. Alluzience® also promises that the effect of the botulinum toxin is constant overtime. One study have shown that 0 out of 595 where positive on neutralising antibodies. This translates to the same results even after years of regularly treating with Alluzience®. Lastly, Bocouture® molecules weigh 150kDa and the same goes for Alluzience®.
Compared to Botox®
Safety & Risks of Alluzience
Positive or negative?
Lets start with the downside of Alluzience® which is actually also one of the most positive sides of this product. Because of the longer results (6 months), you may also have longer side effects if injected wrong. If you would experience any hanging eyelids or eyebrows with another brand for 3-4 months, you may experience longer side effects with Alluzience®. The opposite is also true. You may experience less side effects, because with Alluzience® you are sure that the doctor does not need any calculation beforehand. Thus, he injects always precisely the same dosage.
A sniper or a bazooka?
Is Alluzience® a sniper or a bazooka?
Is it cost effective?
Short answer? Yes and No. This depends on what the clinic asks for Alluzience and other botulinum toxin brands. One may ask for the same price, while others charge more for Alluzience® per zone. This is because of the higher price the clinic pays for the product. You need a longer answer? Lets calculate.
One zone botulinum toxin
Assuming you would pay €20 more per zone. if you normally would pay €120 for one zone, you would have payed €140 for Alluzience® for one zone. If you normally have 4 months result with other brands, you would have 6 months results with Alluzience®. That is 1.5 times longer results. So, €120 x 1.5 = €180 for Alluzience® if you would pay for longer results, right? That means that you have actually spend €180 – €140 = €40 less for botulinum toxin for one zone.
But, what if you have always 5 months result with another brand? That means that 6 months is 1.2 longer results. €120 x 1.2 = €144. You are still €144-€140 = €4 cheaper, than with another brand.
Two zones botulinum toxin
What if you want 2 zones of botulinum toxin? Lets make the calculation:
Now lets assume you pay €220 for 2 zones for another brand and €280 for Alluzience®. If you would have 4 months results with another brand and 6 months with Alluzience®. That is 1.5 times longer results. That means €220 x 1.5 = €330 if you would have payed for the length. €330 – €280 = €50 cheaper with Alluzience®. But, what if you would have 5 months result with another brand and 6 with Alluzience®, that is again €220 x 1.2 = €264. Now you have payed €16 more for Alluzience®.
Three zones botulinum toxin
If you normally pay €300 for 3 zones, now you pay €140 x 3 = €420. Again, if you experience 4 months results with another brand, then €300 x 1.5 = €450. So, you actually pay €30 less for Alluzience®. But, if you experience 5 months with another brand, then €300 x 1.2 = €360. Now you have payed €60 too much for the length of results.
Now the costs are really dependend on the clinic. This is just a sketch for what you possibly can expect for the prices and it is definitely not an indication for the price you will pay. This way you might calculate for what is cheaper for you.
Conclusion
Alluzience® is the newest and first vegan botulinum toxin with longer results compared to other brands. It has similarities compared to Dysport® and Bocouture®. It promises a new way of treatment for patients seeking for improved results. In many cases it might be cost effective and other cases more expensive. Look for a clinic who offers this brand and make sure that you are in good hands.
References
- Rosenthal A, BA; and Moy R, MD et al. Commentary on: Liquid Formulation of AbobotulinumtoxinA: A 6-month, Phase III, Double-blind, Randomized, Placebo-Controlled Study of a single treatment, Ready-to-use Toxin for Moderate-to-Servere Glabellar Lines, Aesthet Surg J. 2020, Vol 40(1) 105-107
- Galderma. Alluzience. SmPC 2021.
- B. Poulain et al. The botulinum J., Vol. 1, No.1, 2008.
- Ascher B, Rzany B, Kestemont P, et al. Aesthet Surg J. 2020;40(1):93-104.
- Kestemont P, Hilton S, Andriopoulos B, et al. Longterm efficacy and safety of liquid formulation abobotulinumtoxin A for the treatment of moderate-to-severe glabellar lines: a Phase III, double-blind, randomized, placebo-controlled and open-label repeat injection study.
- Ascher B, Rzany B, Kestemont P, et al. Aesthet Surg J. 2020;40(9):1000-1008
- Bijsluiter bij AboNT injectiespuit.
- Galderma, Test Report – Evaluation of syringes for use with Alluzience toxin. Data on file (MA-43966).
- Eisele et al. Toxicon 2011;57:555-565.
- Frevert J, Dressler D. Complexing proteins in botulinum toxin type A drugs: a help or a hindrance?. Biologics. 2010;4:325-332. Published 2010 Dec 9. doi:10.2147/BTT.S14902
